The Study
Obesity has been hypothesized to have a negative impact on immune function. In this interesting study, 24 obese and 31 normal weight subjects were fed a standardized diet for 4 weeks and then had a variety of immune factors tested. The subjects were put on the same diet because what we eat can influence our immune system.
The results showed that measures of immune function such as C-reactive protein, T cell activity and white blood cell counts were significantly worse in the obese subjects.
American Journal of Clinical Nutrition 2025;121:1315-27
Take Home Message
Obesity is thought to be associated with a shift away
from immune cell metabolism and toward an increase in glucose metabolism. This
can increase inflammation and reduce the efficiency of the immune system. This
is just another reason to do your best to keep your weight in the normal range.
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