Friday, July 11, 2014

Questions and Answers

What weight loss supplement do you recommend?

The short answer: absolutely none!

The long answer requires a bit of a background. In October 1994, the Dietary Supplement Health and Education Act was signed into law by President Clinton. After this law was in place, manufacturers of dietary supplements did not need approval from the FDA to begin marketing and selling their supplement products. 

This is in direct contrast to pharmaceutical drugs which need to prove that they are both safe and effective before they can be brought to market. 

Following are some of the problems that this law created:
1) Nobody is checking up on the ingredients in these supplements. Often they don’t contain what they say they do, or contain little to none of the advertised active ingredients. 

2) For the same reason, sometimes they contain harmful ingredients like pharmaceutical drugs or even banned substances.  There is really no regulation until there is a report of illness or injury, then the FDA will look into it.  It is up to the FDA to prove that these substances are not safe and they don’t have the resources to test all of the tens of thousands of products on the market.   

3) They never stand up to scientific scrutiny. I read the nutrition literature every month, and whenever an independent university or research institution tests these weight loss supplements, they don’t increase weight loss when compared to a placebo in well-designed randomized controlled trials.

Stay away from weight loss supplements.  At best they are ineffective, at worst they can make you sick.  If weight loss is your goal, there is no substitute for a good diet, the right cardiovascular exercise program and a well-designed strength training routine. 


Research Update

Mediterranean Diet And Diabetes

The Study
In this randomized trial, 3,541 men and women aged 55-80 at high risk of cardiovascular disease were put on one of three diets: a Mediterranean diet supplemented with olive oil, a Mediterranean diet supplemented with nuts, or a low fat control diet. After 4.1 years of follow up, the pooled Mediterranean group had a 30% lower risk of type 2 diabetes when compared to the low fat control group. The authors believed that the Mediterranean diet contains components that decrease inflammation, oxidative stress, and insulin resistance. Annals of Internal Medicine 2014; 160:1-10.

Take Home Message                    
Yet again, the Mediterranean diet is shown to be extraordinarily health promoting.  It is a diet that is 35-40% healthy fat, high in nuts, fruits, vegetables, legumes and fish, and low in butter, sugars, and refined carbohydrate. This study also provides further evidence that a low fat diet is not the way to go.

Glycemic Load And Inflammation

The Study
This paper is a systematic review of the literature on the association between dietary glycemic index/load and markers of inflammation. Nine observational studies and 13 intervention studies were identified for this review. Markers of inflammation in these studies were C-reactive protein (CRP) and Interleukin 6 (IL-6). The researchers found that the majority of studies found a significant association between glycemic index/load and higher levels of inflammation. The authors of the study believe that higher glycemic load diets increase oxidative stress which leads to an inflammatory response by the body. American Journal of Clinical Nutrition 2014; 99:813-33.

Take Home Message
It appears that inflammation is very important in the development of a variety of chronic diseases, such as: type 2 diabetes, heart disease, stroke, dementia, and even some cancers. Swings in blood sugar can have a really powerful impact on our health. Do your best to keep your glycemic load low by substituting fruits, vegetables, legumes, and whole grains for refined grains like bread, pasta, white rice, and sugar.

Research Update: Are nuts health promoting or just fattening?

Association of nut consumption with total and cause specific mortality. New England Journal of Medicine 2013; 369:2001-11.

To examine the association between nut consumption and all-cause mortality.

76,464 women from the Nurses’ Health Study and 42,498 men from the Health Professional Follow up study were followed for 30 years. Nut consumption was measured every 4 years by means of a validated food frequency questionnaire. Risk of death was computed for increasing levels of nut consumption, while statistically controlling for potential confounding variables.

By the end of follow up, there were 16,200 deaths in the Nurses’ Health Study and 11,229 deaths in the Health Professional Follow-up Study. When compared to subjects who never consumed nuts, subjects consuming 7 or more servings of nuts per week had a 20% lower risk of dying. A serving of nuts was considered to be 1 ounce.

There was a statistically significant inverse association between nut consumption and death due to cancer, heart disease, and respiratory disease. The association between nut consumption and a lower risk of morality was actually stronger for subjects that were overweight or obese.

Nuts have long been vilified for their high fat content. Those looking to improve their health or lose weight were told to strictly limit consumption. This was the wrong advice. First of all, nut consumption does not have a major impact on body weight. In both the Nurses’ Health and Health Professional cohorts, less weight gain was seen among subjects with more frequent nut consumption.

Nuts are also an extremely healthy food. They contain unsaturated fatty acids, fiber, vitamins, minerals, antioxidants, protein, and other beneficial phytochemicals. The authors noted that the combination of these components has been shown to be cardio-protective, anti-carcinogenic, and anti-inflammatory.  That is likely why those who consume nuts frequently have a lower risk of dying.

Take Home Message
Nuts are a very important part of a healthy diet. Do not fear them, but appreciate them and enjoy them on a daily basis.

Book Review: Grain Brain

Next up for review is Grain Brain. The author, Dr. David Perlmutter, is a Board Certified Neurologist and president of the Perlmutter Health Center in Naples, Florida.

Grain Brain really has one central theme; that the wrong type of carbohydrate can destroy the human brain. The book is broken down into 3 sections: 1) The science part: this section covers how the brain works, all about gluten, and how the wrong type of carbs can cause problems. 2) The lifestyle part: this section covers the proper diet and exercise program to optimize brain function. 3) Meal plans and recipes. The book is 285 pages and is very well written. I truly enjoyed reading it.

5 Things I Really Liked About Grain Brain
1) I really enjoyed learning about the human brain. While I have studied anatomy and physiology in the past, this book really gets into the inner working of the brain and how our lifestyle can help it to flourish or slowly destroy it. It really is a miracle organ.

2) The part of the book that discusses the link between blood sugar and brain function was fascinating. As the research begins to pile up in this area, it was really nice to get a detailed explanation of the potential mechanisms that may be at play here. Very few people truly understand the importance of maintaining a stable blood sugar, as nature intended. It makes me sad when I think of how our country is eating right now.

3) The section on sleep was really interesting. Sleep deprivation will adversely affect just about every part of your body, especially your brain. Seven hours per night should be your absolute minimum goal.

4) As an exercise physiologist, the chapter on physical activity and optimal brain function was fascinating. I knew that exercise is important for brain health, but I was surprised that it was the most important factor. When speaking of preventing brain shrinking and cognitive flexibility, Perlmutter notes that there is no better tool than physical activity. 

5) In Grain Brain, a good amount of time is spent discussing the problems with a low fat, high carbohydrate diet. The author strongly feels that this style of eating is not the path to weight loss or improved health. I couldn’t agree more.

5 Things I Didn’t Agree With In Grain Brain
1) When covering carbohydrate containing foods, the author utilizes the glycemic index, a standardized measure of how a carbohydrate food will influence blood sugar. However, he completely ignores the concept of glycemic load. This measure takes into account both the glycemic index and the amount of carbohydrate in a serving. The glycemic load will give you a much more practical look at how a food will impact blood sugar and insulin levels and it should have been discussed.

2) Grain Brain recommends only 60 grams of carbs per day. This is only 12% of calories on a 2000 calorie diet. Since 20% of protein is about as high the body will let you go, this diet breaks down to 12% Carb, 20% Protein, and 68% Fat. This is a ton of fat, and as mentioned later, much of the fat that he recommends is saturated fat. This level of carb restriction has also been demonstrated in the literature to be very hard to sustain.

3) Grain Brain includes a liberal consumption of saturated fats. Coconut oil, beef tallow, butter, and cheese are all allowed on a daily basis. I don’t think this much saturated fat is a good idea.

4) Grain Brain strictly limits other foods that are health promoting such as whole grains, fruits, and legumes. 

5) I was a bit confused by the references. The book had a ton of references and some were from very reputable journals, like the Journal of the American Medical Association and The New England Journal of Medicine. However, a significant percentage of his references were from quite unscientific sources, such as YouTube videos, blogs, Dr. Oz’s website, New York Times science writers, etc. These references do not prove much scientifically, they are just the opinion of the author. In most cases, the author was not a researcher or educated in the research sciences in any way.

Is Grain Brain Worth Reading?
Absolutely! I really enjoyed this book. You’ll learn a lot about the human brain and how to take care of it. While I don’t agree with many of the dietary recommendations, this much is clear; the proper diet, plenty of exercise, and the right amount of sleep can help keep your brain working until a ripe old age. This is of the utmost importance, because at the end of the day, if your brain isn’t working, what kind of life can you have, really?