218 overweight women were randomly assigned to 2,000 IU of vitamin D or placebo for 12 months. Both groups received the same weight loss advice, which included comprehensive dietary change and 225 minutes of cardiovascular exercise per week. After 12 months, there was no significant difference in weight loss between the two groups. The vitamin D group lost 8.2% of their baseline body weight, while the placebo group lost 8.4% of their baseline weight. American Journal of Clinical Nutrition 2014; 99:1015-25.
Take Home Message
In some cross-sectional
studies, vitamin D levels have been inversely associated with obesity. However,
it appears that vitamin D supplementation does not increase weight loss. This
was a very well designed study with good adherence and a long duration. Once
again, another promising weight loss supplement fails to live up to the rigors
of a randomized trial. I guess there is just no substitute for proper diet and
exercise if weight loss is your goal.
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